Combined analyses revealed that in addition to proteins commonly required for cell proliferation (positive controls; yellow dots), these CRISPR screens identified ITGAV (encoded by the ITGAV gene) as the top essential cell surface protein in multiple cells representative of cancer types (Fig. 1c and Supplementary Table 3; additional analyses of these surface proteome screens are shown in Extended Data Fig. 2). Here, ITGAV is linked to cancer.