ITGAV and cancer: To pinpoint the critical components within the integrin family that collaborate with ITGAV for cancer cell maintenance, we developed another CRISPR library targeting the gene coding regions of each of the 26 integrin subunits with 25 sgRNAs per gene (Extended Data Fig. 1c and Supplementary Table 2; total 650 sgRNAs plus control sgRNAs) for a CRISPR depletion screen in the Cas9+ MDA231 and PANC1 cells (Fig. 3b).