NDUFS7 and Leigh syndrome: Only one of them was located in a functional candidate gene for Leigh syndrome, in NDUFS7. This variant, Chr20:57,913,322G > A or XM_038568001.1:c.535G > A, is predicted to result in an amino acid substitution in a highly conserved region of the encoded NADH:ubiquinone oxidoreductase core subunit S7, XP_038423929.1:(p.Val179Met) (Fig. 5).