ACE and obesity due to melanocortin 4 receptor deficiency: The development of obesity-induced hypertension could be returned to over-activation of the sympathetic nervous system producing hypertension in obese humans and animal models as reported by77–79 assumed the mechanism of action of chia seeds which may involve the presence of peptides acting as angiotensin-converting enzyme inhibitors, and thus improve the blood pressure as reported in type 2 diabetes patients.