To explore the molecular mechanisms underlying aneuploid teratoma metastasis, we performed single-cell RNA sequencing (scRNA-seq) analyses of six lung metastases derived from Ts6, Ts8, Ts11, Ts6 + 8, and Ts8 + 15 ESCs (designated Ts6-M, Ts8-M, Ts11-M, Ts6 + 8-M, Ts8 + 15-M1 and Ts8 + 15-M2) and seven primary teratoma samples (designated WT-P, Ts6-P, Ts8-P, Ts11-P, Ts15-P, Ts6 + 8-P and Ts8 + 15-P), respectively. The gene discussed is ASNS; the disease is teratoma.