Following the removal of tetracycline for 15 days, a CML-like disease was established, with an increase in Gr-1+CD11b+ cells in the blood and BM of mice transplanted with WT:CML BM (Fig. 1b, c; Supplementary Fig. 1d). Here, ITGAM is linked to chronic myelogenous leukemia, BCR-ABL1 positive.