Finally, as we identified in the mouse model of CML that macrophages exposed to the leukaemic environment displayed a more immature phenotype (Fig. 3d, e; Supplementary Fig. 6a), we sought to investigate the effect of LTF and CD36 suppression on THP-1 CD11b expression. Here, ITGAM is linked to chronic myelogenous leukemia, BCR-ABL1 positive.