Analysis of the BM upon sacrifice revealed that CML induction increases the percentage of CD45.1 Lin−c-Kit+ (LK) progenitor cells compared to control but had no significant effect on the frequency of Lin−Sca-1+c-Kit+ (LSK) cells or more primitive LT-HSCs (Supplementary Fig. 2a–d). Here, KIT is linked to chronic myelogenous leukemia, BCR-ABL1 positive.