GCG and Insulin resistance: In addition, DNL in WAT produces other bioactive fatty acids such as fatty acid ester of hydroxyl fatty acids (FAHFAs), a new class of lipids that are important contributors to the improvement of Insulin Resistance (IR)3–5 and suppression of inflammation in adipose tissues (ATs) by stimulating intestinal cells to secrete glucagon-like peptide 1 (GLP-1), pancreas to release insulin, immune cells to reduce inflammatory cytokine production, as well as enhancing glucose transport in the cells6–9.