We identified 18 CD8+ T cell clones (4 patients: 2 flare, 2 DFR), four CD4+ T cell clones (4 patients: 2 flare, 2 DFR), and no B cell clones which showed a significant change in circulating proportional abundance at onset of arthritis flare (Supplementary Figs. 12 and 13 and Supplementary Table 1). This evidence concerns the gene CD4 and arthritic joint disease.