The gene designated DEAD-box RNA helicase 3X (DDX3X) encodes an RNA helicase protein that assumes a central role in the development of several carcinomas, such as renal cell carcinoma, hepatocellular carcinoma (HCC), prostate cancer, lung cancer, and colorectal cancer [19–24]. Here, DDX3X is linked to hereditary clear cell renal cell carcinoma.