Furthermore, CD8+ T cells isolated from the spleens of Ifnar-/- or α-IFNAR-treated ZIKV-infected C57BL/6 mice exhibited similar levels of antigen-independent cytotoxicity against YAC-1 tumor cells, further suggesting that bystander activation and cytotoxic function occurs independent of the amount of infectious viral particles (Fig. 7e). The gene discussed is CD8A; the disease is neoplasm.