RNA-Seq analysis of FPD-MM cells also showed that HHT treatment caused log2-fold decline in mRNA of MYC, MYB, MCM2/4, FOXM1 and myeloperoxidase (MPO) but increase in CDKN1A, CDKN2B, BCL2A1, ATF3/4, PMAIP1 and HMOX1 (Fig. S4D). This evidence concerns the gene CDKN2B and Miyoshi myopathy.