YAP1 and neoplasm: Furthermore, several tumor-associated YAP fusions that result from chromosomal translocations have been identified in patient samples (3) and we and others have shown that, among other things, these fusions stabilize oncogenic YAP activity through a constitutive nuclear localization of the fusion protein, mediated through nuclear localization signals in the sequence of the C-terminal fusion partners (4, , –7).