TNF and insomnia: Some studies on the effect of SDOL intervention on sleep deprivation model rats found that the spatial learning and memory ability of rats in the SDOL group was increased, the escape latency was shortened, the serum IL-1β and TNF-α content decreased, the content of 5-HT in the raphe nucleus decreased, and the BDNF protein level in the hippocampus was significantly upregulated [43], which may also be one of the mechanisms by which SDOL improves insomnia and nerve injury in patients after stroke.