The difference lies in the different components and action targets in the patent medicine; ESZ+MIR, ESZ+AGO and ESZ+ESC are combination therapies of ESZ and antidepressants; FMT in ESZ+FMT are a compound preparation, which is composed of flupentixol and melitracen, and it has good clinical efficacy in the treatment of anxiety and depression. Here, FBXW7 is linked to depressive symptom measurement.