Nominal prolongations of prothrombin time (PT) and/or activated partial thromboplastin time (APTT) were also observed; however, prolongations were not confined to or notably more severe in the individuals that underwent unscheduled euthanasia; fibrinogen was consistently increased (as opposed to decreased, the expected directionality of change with disseminated intravascular coagulation); additionally, there was no microscopic evidence of intravascular coagulation, such as microthrombi in glomerular or pulmonary capillaries. This evidence concerns the gene F2 and Disseminated intravascular coagulation.