Numerous tools were examined, such as the Protein Kinase CAMP-Initiated Reactant Subunit Alpha (PRKACA) overflow, a significant cell signaling pathway that may be linked to the onset of depression by regulating synaptic pliancy, cytokinesis, transcriptional guidance, and the hypothalamic-pituitary-adrenal (HPA) axis [10]. This evidence concerns the gene PRKACA and depressive disorder.