IL4 and asthma: In the early stage of life (from infancy to childhood), the rates of IL-4 over-exposure-related diseases (e.g., asthma, eczema, and aeroallergen sensitization) and food allergy are significantly higher in males (Rosario et al. 2021; Yung et al. 2018; Chen et al. 2003; de Marco et al. 2000; DunnGalvin et al. 2006).