Diffuse gliomas with MYB/MYBL1 rearrangement were mainly presented in children (Wefers et al. 2020), and most of the patients had epileptic seizures together with neurological symptoms such as movement disorders, behavioral or memory changes (Titulaer et al. 2013; Quiroz Tejada et al. 2021). Here, MYBL1 is linked to central nervous system cancer.