IDH1 and neoplasm: It has been reported that patients with IDH1-wild type glioma were more likely to have impairments in verbal memory, language, visual construction, and manual dexterity more frequently (Wefel et al. 2016), which may be due to the rapid proliferation of tumor cells and lack of compensatory functional reconstruction of the brain rather than metabolic regulation of the tumor microenvironment (van Kessel et al. 2017).