In a recent study that aimed to characterize the immune-oncology gene expression profile in sinonasal undifferentiated carcinomas (SNUCs) and other high-grade sinonasal carcinomas, PRAME was the top upregulated gene in SNUCs and SWI/SNF-deficient sinonasal carcinomas (fold change 8.40), and fold change half values (4.8) were observed for high-grade neuroendocrine carcinomas (HGNECs) [32]. The gene discussed is PRAME; the disease is nasal cavity and paranasal sinus carcinoma.