And IHC staining of OTUB1, KI67, RACK1, p-ERK, p-AKT, and p-FAK supported that efficient OTUB1 knockdown ameliorated the hyperactivation of the oncogenic pathway (Fig. 3f, g), and corroborated the reduced subcutaneous tumor growth when OTUB1 silenced. Here, AKT1 is linked to neoplasm.