In the context of breast cancer cells, the activation of Peroxisome Proliferator-Activated Receptor γ (PPARγ) triggers an upregulation of HIF1α expression, and HIF1α, in turn, mediates PPARγ-induced activation of autophagy, thereby promoting the survival of MDA-MB-231 breast cancer cells [52]. The gene discussed is PPARG; the disease is breast carcinoma.