In accordance with previous reports [3, 10, 12, 47], the positive association found between the endotoxin LPS, LBP, zonulin and S100A8 with fasting insulin and the HOMA index as well as the negative correlation with the QUICKI underline the link between intestinal permeability and insulin resistance and, consequently, the development of T2D. The gene discussed is HP; the disease is Insulin resistance.