In line with the results found in human samples, a downregulation of Nlrp6 in the jejunum from rats with DIO was found, which is in agreement with previous results showing that the reduced gene expression levels of intestinal Nlrp6 in obesity has been efficiently reversed by RYGB but not by caloric restriction [63]. The gene discussed is NLRP6; the disease is obesity due to melanocortin 4 receptor deficiency.