Chen et al. (2020) demonstrated that the combination of CDO1, SOX17, and HOXA7 had the ability in distinguishing the smallest lung nodules among 1.1–2.0 cm (sensitivity 74%; specificity, 93%), while the combination of CDO1, TAC1, and SOX17 was best in tumor sizes < 1.0 cm (sensitivity 71%; specificity, 82%). The gene discussed is CDO1; the disease is neoplasm.