Recently, Hu et al. (Hu et al. 2023) constructed a noninvasive 7-DMR model (7 differentially methylated genes, HOXB4, HOXA7, HOXD8, ITGA4, ZNF808, PTGER4, and B3GNTL1) to discriminate lung cancers and non-lung cancers including benign lung diseases and healthy controls, with a sensitivity of 81% and a specificity of 98%. Here, HOXB4 is linked to lung carcinoma.