HOXB4 and lung cancer: For instance, Hu et al. (2023) developed a “7-DMR model” (7 differentially methylated genes (HOXB4, HOXA7, HOXD8, ITGA4, ZNF808, PTGER4, and B3GNTL1) to distinguish lung cancers from benign nodules, achieving the sensitivities of 89%/92%, specificities of 94%/100%, and accuracies of 90%/94% in the discovery cohort and validation cohort.