HDAC2 and head and neck squamous cell carcinoma: Moreover, it was also reported that most Kcr regulators, including DPF2, KAT2B, and HDAC2–3, were significantly dysregulated in patients with head and neck squamous cell carcinoma (HNSCC); this observation positively correlated with lymph-node metastasis, T stage, and histologic grade [126].