HDAC2 was overexpressed in patients with versus without lymph-node metastasis (p = 0.035); thus, these data indicated that the progression of HNSCC is closely related to Kcr regulators, and it is vital to further classify the potential essential mechanisms of Kcr and these regulatory enzymes for HNSCC metastasis and progression. Here, HDAC2 is linked to head and neck squamous cell carcinoma.