HDAC1 and glioblastoma: HDAC1 was found to be overexpressed in GBM, as well as inhibit the expression of solute carrier family 30 member 3 (SLC30A3) by inducing the deacetylation of histone H3K27 of SLC30A3 around the super-enhancer region, thus hampering the outgrowth and metastasis of GBM cells [155].