SIRT7 and glioblastoma: In human U251 glioblastoma (GBM) and HEK-293 cells, KAT2A depletion expectedly decreased the level of Ksuc in specific gene promoter sites [53]; SIRT7 is recruited to DNA DSBs dependent on poly(ADP-ribose) polymerase 1 (PARP1), thereby promoting DSB repair and chromatin condensation [56].