SEPTIN2 and hepatocellular carcinoma: However, emerging evidence also highlights the positive relationship between novel acylation and HCC; it was documented that the Kcr of Septin 2 (SEPT2) promotes the invasion of HCC cells, with the SEPT2 in highly invasive HCC cells significantly hypercrotonylated; conversely, the K74 mutation of SEPT2 delayed its Kcr, leading to decreased GTPase activity of SEPT2 and impaired HCC metastasis in vitro and in vivo [142].