In ocular melanoma cells, aerobic glycolysis-derived histone Kla elevation increased the expression of YTH (YT521-B homology) domain 2 (YTHDF2), which binds to the m6A sites of TP53 and PER1 mRNAs for RNA degradation, thereby contributing to the aggressiveness of ocular melanoma cells [177]. This evidence concerns the gene PER1 and ocular melanoma.