Because of the antiangiogenic effects of E-P125A (14), we investigated the effects of αEGFR-E-P125A on angiogenic signaling genes and proteins in tumor cells themselves and found decreased expression of angiogenic genes such as VEGFA, PTK2, ANGPT1, ITGAV, and ITGA5, and decreased phosphorylation of FAK protein at Y397 and total levels of α5 integrin. The gene discussed is ITGA5; the disease is neoplasm.