HMGB1 and Hip dysplasia: Dysregulation senescence markers (e.g., HMGB1, Cdkn1a, Cdkn2aink4a) and inflammation markers (e.g., MMP3, IL‐6b, MMP13) were further validated with qRT‐PCR, confirming treatment with Col11a1‐OE organoids remitted inflammation and prevented cellular senescent state of chondrocytes in DDH progression (Figure 9H).