Interestingly, we found OXPHOS‐associated genes (e.g. COX17, ATP5F1B, COX7A2 ...) were significantly up‐regulated and glycolysis‐associated genes (e.g. GLUT1, HK2, LDHA ...) down‐regulated with Col11a1 deficiency (Figures 6A and B), which was consistent previous reports in cellular senescence and degenerative joint diseases.37, 38, 39. The gene discussed is COX7A2; the disease is osteoarthritis.