As interleukins play a pivotal role in the formation of NETs, Yazdani et al., 2017 showed that IL-33 is released from liver sinusoidal endothelial cells to promote NET formation during liver ischemia–reperfusion, exacerbating inflammatory cascades and sterile inflammation Nie et al., 2019 demonstrated that IL-8-induced NET formation promoted diffuse large B-cell lymphoma progression via TLR9 signaling. The gene discussed is CXCL8; the disease is diffuse large B-cell lymphoma.