Wang et al., 2023 showed that PSTPIP2 is associated with sepsis and can regulate the expression of inflammatory factors by modulating the NF-κB pathway. Pavliuchenko et al., 2022 reported that molecular interactions involving the adaptor protein PSTPIP2 control neutrophil-mediated responses, leading to autoinflammation (Pavliuchenko et al., 2022). Furthermore, in a previous study, we identified a pivotal role of PSTPIP2 in cisplatin-induced AKI (Zhu et al., 2020). The gene discussed is NFKB1; the disease is acute kidney injury.