In synovial fibroblasts of patients with rheumatoid arthritis Tumor Necrosis Factor (TNF) drives the expression of Jagged-2, Notch-1, and Notch-4, along with a hallmark of Notch activation, the Notch intracellular domain (NICD) nuclear translocation (8). The gene discussed is NOTCH4; the disease is rheumatoid arthritis.