Jagged-1 has been correlated with oral carcinogenesis as its levels are progressively increased from oral epithelial dysplasia to infiltrative squamous cell carcinoma (19), while in head and neck carcinomas its overexpression is thought to promote crosstalk between endothelial and tumor cells (19), triggering its activation in endothelial cells and facilitating tumoral angiogenesis and growth (17). The gene discussed is JAG1; the disease is head and neck carcinoma.