A gain-of-function due to alteration in the Flt3 gene activates other intracellular signal pathways, including mitogen-activated protein kinases (MAPK), signal transducer and activator of transcription (STAT), and AKT crucial in inducing an uncontrolled cell proliferation and cell death resistance in AML (Fig. 1) [23]. Here, AKT1 is linked to acute myeloid leukemia.