According to general logic, elevation in serum ANA titer often signifies increased activity within one or more plasma cells present within the patient’s body and consequently suggests heightened disease activity within their case of SLE; however, this is not always true (24, 25) due to various factors such as assay variation (26), substrates used during testing procedures (27), formation of immune complexes (28), and protein loss from kidney (11, 12). The gene discussed is BTG3; the disease is systemic lupus erythematosus.