This suggests that subjective attitudes among PLWH have a strong influence on willingness to be vaccinated because our research found that none of the HIV-related characteristics had a significant effect on the COVID-19 vaccination willingness, including time living with HIV, mode of HIV transmission, clinical stage, the symptoms associated with HIV infection the last 3 months, and the last CD4+/CD8+cells. The gene discussed is CD8A; the disease is HIV infectious disease.