Similar to the above-mentioned hypothesis of stress-induced changes in DNA methylation state upon delivery by CS, several studies have reported that DNA methylation of NR3C1 gene could be affected by epigenetic factors such as quality of maternal care and experience of prenatal and childhood trauma (35, 80–83) which may lead to neuropsychiatric disorders, e.g., depression, anxiety and post-traumatic stress disorder. This evidence concerns the gene NR3C1 and major depressive disorder.