Subsequently, MIA2 and MIA3 (TANGO1) were discovered, and although there is little evidence linking them to melanoma, they have been shown to be involved in other cancers: overexpressed TANGO1 provides a link to oncogenesis through promoted expression of CHAC1 and degradation of glutathione (GSH), thereby promoting the growth and metastasis of hepatocellular carcinoma cells, while its knockdown blocks tumour growth and metastasis (Wanbiao et al., 2023). The gene discussed is MIA3; the disease is melanoma.