In the ChIP-Seq database (http://chip-atlas.org/;https://www.grnpedia.org/trrust/), we found that both PPARA and PPARG might transcriptionally regulate ACSL1 expression, another member of the ACSL family (Fig. 5C), which has been reported to mediate αESA-induced ferroptosis in breast cancer cells [27]. The gene discussed is PPARA; the disease is breast cancer.