For the diagnosis of ARF, the revised Jones criteria are employed, which include major criteria such as chorea, erythema marginatum, subcutaneous nodules, polyarthritis, and carditis, while minor criteria involve polyarthralgia, fever, sedimentation rate at or more than 60 mm and/or C-reactive protein (CRP) at or more than 3.0 mg/dl, and prolonged PR interval [2]. Here, CRP is linked to inflammation of heart layer.