MAPT and Alzheimer disease: AD is characterized by the development of extracellular amyloid-ß plaques and neurofibrillary tangles (NFT) in the intracellular environment, neuronal death, and synaptic loss, all of which lead to progressive cognitive impairment [1]. The pathogenesis of AD, a neurodegenerative illness, has been linked to intracellular NFTs composed of hyperphosphorylated tau protein and extracellular aggregates of amyloid ß-plaques in the cortical and limbic regions of the human brain [1].