IL33 and adenocarcinoma: Emerging studies of IL-33 in mice also demonstrated contradictory results of promotion or inhibition [22-24]. Furthermore, Cui et al. found the expression of IL-33 was higher in early colonic adenomas when compared to adenocarcinoma [25]. Others have found that decreased IL-33 expression is associated with advanced human CRC, and increased expression showed reduced vascular invasion and LN metastasis [23]. From this debate, one can propose that studying additional factors may dissolve the intermingling condition.