SETD2 and cancer: Similarly, several studies pointed to the wide, complex role of HIF 1-α in cancer including various interactions with growth factors and growth factor receptors [27], several effects on glycolytic enzymes such as the lactate dehydrogenase, promoting the production of ATP to sustain cell proliferation [28], regulating the natural killer cell mediating the antitumor effects and preventing cytotoxic response on tumor cells [29] and the upregulation of autophagy and escaping apoptosis particularly in CRC [30].