It has also been reported that the release of NF-κB and proinflammatory cytokines during rheumatoid arthritis leads to the classical symptoms such as synovial hyperplasia, pannus formation, and joint and bone disintegration in addition to the infiltration of the synovium by inflammatory cells which then destroys the synovial membrane [29, 30]. The gene discussed is NFKB1; the disease is rheumatoid arthritis.