Interestingly, Chun et al. found uromodulin mutations in a rather large subgroup of sFSGS patients that were then classified as Autosomal Dominant Tubulointerstitial Kidney Disease (ADPKD), which has been previously linked to uromodulin gene variants [48]. Here, UMOD is linked to autosomal dominant medullary cystic kidney disease with or without hyperuricemia.