THBS1 and neoplasm: For instance, nuclear expression of FSP1 correlates with poor prognosis in ovarian carcinomas, which suggests the potential importance of localization of FSP1.On the other hand, treatment of tumor cells with the FSP1 resulted in the stabilization of p53 and modulation of genes regulated by it, including mouse double minute 2 (mdm2), Bcl-2-associated x (Bax), p21, and thrombospondin-1 (THBS1).