To illustrate this novel recruitment and differentiation of CAFs, specific examples are included here: In the case of prostate cancer, CXC motif chemokine receptor 6 (CXCR6) signaling mediated by CXCL16 supports the migration of MSCs, which is abolished following the knockdown of CXCL16 (10). This evidence concerns the gene CXCL16 and prostate carcinoma.