In addition, NF-κB induces the release of the inflammatory factor IL-6, leading to the signal transducer and activator of STAT3 activation, which promotes hepatocyte repair and replication capacity and inhibits apoptosis, thereby promoting the development of hepatocellular carcinoma (Ringelhan et al., 2018). This evidence concerns the gene NFKB1 and hepatocellular carcinoma.