Regarding NAFLD, we specified TG and TC as the primary indicators of fatty liver and AST, ALT, LDL, HDL, MDA, GSH, TNF-α, IL-6, and IL-1β as the secondary outcome indicators for quantitative analysis and found that curcumin intervention at doses of 50–200 mg/kg for 4 to 16 weeks significantly reduced TG and TC levels and significantly improved NAFLD-induced oxidative stress and inflammatory factors. The gene discussed is TNF; the disease is fatty liver disease.