In addition, eight studies reported the TNF-α level in liver fibrosis models, and the results demonstrated that treatment with curcumin could significantly reduce the TNF-α level compared to that in the liver fibrosis model group [n = 132, SMD = −4.57, 95% CI (−6.38, −2.76), p < 0.0001] (Figure 8A). This evidence concerns the gene TNF and Hepatic fibrosis.