Curcumin can ameliorate oxidative stress by inhibiting the activity of CAT and SOD and reduce the expression of transforming growth factor TGF-β and tumor necrosis factor TNF-α by inhibiting the activation of NF-κB, thus improving LF and preventing the development of HCC (Hu et al., 2023). The gene discussed is SOD1; the disease is hepatocellular carcinoma.