Curcumin ameliorates steatosis by phosphorylating adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) and thereby inhibiting preadipocyte differentiation, inhibiting downstream target proteins CCAAT-enhancer-binding proteins (C/EBP), peroxisome proliferator-activated receptor γ (PPARγ), and sterol regulatory element-binding protein-1c (SREBP-1c) and decreasing hepatic TG levels. This evidence concerns the gene SREBF1 and steatosis.