To characterize the role of apoM on atherosclerosis and lipid metabolism, a panel of apoM gene-modified mice has been generated using the endogenous promoter (express apoM in liver and kidney) (Christoffersen et al., 2008b), the apoE promoter (express apoM primarily in liver) (Liu et al., 2014), and adenovirus (express apoM in liver) (Kurano et al., 2013). This evidence concerns the gene APOM and atherosclerosis.