SYNPO and systemic lupus erythematosus: Additionally, through downregulation of nephrin and synaptopodin expression, and interfering with slit diaphragm function and cytoskeletal dynamics, (Maeda et al., 2018), targeted delivery of CAMK4 inhibitors preserved podocyte architecture, prevented the progression of glomerulonephritis in mice predisposed to lupus, and repaired mice’s podocyte damage brought on by adriamycin.