In terms of the underlying neuropathology, FTD is mainly associated with pathological accumulation of TAR-DNA-binding protein-43 (TDP-43; FTD-TDP) or microtubule-associated protein tau (FTD-tau) and, less commonly, fused in sarcoma (FTD-FUS) (van der Ende & van Swieten, 2021). The gene discussed is TARDBP; the disease is frontotemporal dementia.