Accompanying manuscripts by Arnold et al. and Zeng et al. investigate APA dysregulation more generally upon TDP-43 loss and show it is widespread, in accordance with our findings in Fig. 1B, can occur in ALS-FTD related genes (Zeng et al., co-submitted) and can lead to change in function (Arnold et al., co-submitted), underscoring the potential relevance of APA in disease pathogenesis. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.