↓ Hepatic tumorigenesis and lung tumor incidence; ↑ hepatic SIRT1 protein and deacetylation of SIRT1 targets; ↓ caspase-1 activation and SIRT1 protein cleavage; ↑ glucose intolerance; ↓ hepatic inflammation. The gene discussed is SIRT1; the disease is Glucose intolerance.