The omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) inhibits the development of HCC induced by DEN and HFD, suggesting that EPA attenuates the development of obesity-related MASLD-HCC by suppressing STAT3 (Inoue-Yamauchi et al., 2018). The gene discussed is STAT3; the disease is hepatocellular carcinoma.