Curcumin inhibited hepatic tumorigenesis in a C57BL/6J male mice MASLD-related HCC model challenged with STZ and a HFD by inhibiting hepatic C/EBPβ, CYP2E1, p-ERK1/2, and p67phox, while upregulating Nrf2 (Afrin et al., 2017). This evidence concerns the gene NFE2L2 and hepatocellular carcinoma.