↓ HCC development (incidence, multiplicity, and tumor volume); ↓ hepatic inflammatory foci development; ↓ IL-1β, IL-6, IL-12α, monocyte chemoattractant protein-1, and iNOS (mRNA); ↑ sirtuin mRNA; ↑ hepatic circadian clock genes; ↑ gut microbial richness and diversity; ↓ relative abundance of the genera Clostridium and Mucispirillum. This evidence concerns the gene CLOCK and hepatocellular carcinoma.