↓ Liver and peritumoral fibrosis; ↑ anti-PD-1-induced tumor regression; ↑ HCC infiltration by effector CD8+ T cells compared to the PD-1 blockade alone. The beneficial effects of losartan correlated with blunted TGF-β receptor signaling, reduced collagen deposition, and depletion of immunosuppressive fibroblasts. This evidence concerns the gene CD8A and hepatocellular carcinoma.