Scoparone inhibits activation of mitogen-activated protein kinase (MAPK)/Akt signaling and reverses upregulation of NF-κB p65 and its target genes, including NF-κB, TNF-α, cyclooxygenase (COX-2), MCP-1, iNOS, and MMP-9, in MASLD-HCC models (Ye et al., 2023). The gene discussed is NFKB1; the disease is hepatocellular carcinoma.