SNAI1 and neoplasm: Two new deubiquitinating enzymatic enzymes, PSMD14 with OTUB1, can inhibit the ubiquitination level of Snail and hinder its proteasomal degradation pathway, thus enabling the accumulation of Snail in cells, and activating the Snail-mediated epithelial-stromal transformation process to promote tumor progression and metastasis in esophageal squamous carcinoma (Jing et al., 2021; Zhou et al., 2018).