It was found that CUL4A and nuclear transcription factor NF-κB were overexpressed in both gastric and pancreatic cancer tissues, and the expression of CUL4A and atomic transcription factor NF-κB was positively correlated in tumor tissues, suggesting that CUL4A may promote the invasion of malignant tumors by regulating NF- κB signaling pathway (Gong et al., 2017). The gene discussed is NFKB1; the disease is familial pancreatic carcinoma.