TNF and Sepsis: Although satisfactory results have been obtained in animal models for blocking cytokine activity such as TNF-α (Dinarello, 1991), IL-17 (Wynn et al., 2016), and IL10 (Kalechman et al., 2002), the results in clinical trials on patients with sepsis are not clear (Lv et al., 2014; Rizvi & Gallo De Moraes, 2021).