RT-PCR results showed that IL-1β gene expression in the DM group was much higher than that in the control group (2.0 ± 0.24 vs 1.0 ± 0.37, P = 0.0427; Fig. 7D; original data: Table S7) and DMES group (2.0 ± 0.24 vs 0.90 ± 0.51, P = 0.0341; Fig. 7D; original data: Table S7), while no significant difference was found between the control and DMES group (1.0 ± 0.37 vs 0.90 ± 0.51, P = 0.8871; Fig. 7D; original data: Table S7). The gene discussed is IL1B; the disease is diabetes mellitus.