Compared with the non-heart failure group, the heart failure group has a higher proportion of chronic renal insufficiency, a lower LVEF, and higher levels of NT-proBNP, serum creatinine, fasting blood glucose, blood cholesterol, triglyceride, and low-density lipoprotein cholesterol, with statistically significant differences (all P < 0.05), as shown in Table 1. The gene discussed is NPPB; the disease is chronic kidney disease.