Based on the above functional enrichment results of this cluster and the known involvement of several members in neurological disease and cancer development, including Cdk5r1, Dlgap1, Stx1b, Scn8a and Nrxn1 (63–68), it is reasonable to hypothesize that the genes of this cluster are part of a more complex disease pathway. Here, CDK5R1 is linked to nervous system disorder.