Based on the above functional enrichment results of this cluster and the known involvement of several members in neurological disease and cancer development, including Cdk5r1, Dlgap1, Stx1b, Scn8a and Nrxn1 (63–68), it is reasonable to hypothesize that the genes of this cluster are part of a more complex disease pathway. The gene discussed is SCN8A; the disease is nervous system disorder.