While therapeutic STING agonism coordinately enhanced expression of the Arg2, Isg15, Nos2, and Pdl1 (Cd274) immuno-suppressive/regulatory ISGs in both melanoma models, Cox2/Ptgs2 expression was selectively upregulated by ADU-S100 treatment only in the B16 model. The gene discussed is PTGS2; the disease is melanoma.