In BPR20 tumors treated with ARG2i/COX2i/NOS2i, an increase in CD45+ immune cell infiltration into the tumor was observed, corresponding with increases in gene transcripts associated with immune cell-mediated tumor growth control and inflammation (e.g., Ccl21a, Fasl, Cd8b1, Cd40, Cd4, Cxcl11). Here, CD4 is linked to neoplasm.